Yuning is a chemist with a background in novel transition metal catalyzed methodology development enabled by high throughput chemistry.
Yuning obtained her PhD in medicinal chemistry from University of Michigan under the supervision of Dr. Tim Cernak. Her research focused on identifying new reactivity, achieved by copper catalysis for amine–acid coupling facilitated by cheminformatic analysis. Such method development is enabled by nanoscale synthesis on a high throughput chemistry platform that was established in Tim’s lab.
Outside of lab, she likes to play video games and spend time with her cats.
Shen, Y., Mahjour B. and Cernak, T., Development of deaminative esterification using high-throughput experimentation. Commun. Chem., 5, 83 (2022).
Shen, Y., Borowski, J.E., Hardy, M.A., Sarpong, R., Doyle, A.G. and Cernak, T., Automation and computer-assisted planning for chemical synthesis. Nat. Rev. Methods Primers, 1,1-23 (2021).
Mahjour, B., Shen, Y. and Cernak, T., Ultrahigh-Throughput Experimentation for Information-Rich Chemical Synthesis. Acc. Chem. Res., 54, 2337-2346, (2021).
Lin, Y., Zhang, Z., Mahjour, B., Wang, D., Zhang, R., Shim, E., McGrath, A., Shen, Y., Brugger, N., Turnbull, R. and Trice, S., Reinforcing the supply chain of umifenovir and other antiviral drugs with retrosynthetic software. Nat. Commun., 12, (2021).
Mahjour, B., Shen, Y., Liu, W., & Cernak, T., A map of the amine–carboxylic acid coupling system. Nature, 580, 71-75 (2020).
Shen, Y., Lee, W.C.C., Gutierrez, D.A. and Li, J.J., Palladium-Catalyzed Direct C(sp2)–H ortho-Arylation of Anilides Using 2-Aminophenylpyrazole as the Directing Group. J. Org. Chem., 82, 11620-11625 (2017).