Calvin is a chemistry apprentice at Octant on the high-throughput synthesis team. He graduated from Notre Dame with a B.S. in biochemistry, concentrating in neuroscience and minoring in patient advocacy. In the Serianni Lab at Notre Dame, he synthesized carbohydrates and glycoconjugates to study the three-dimensional structure and conformation of these biomolecules using NMR.

Calvin has prior experience in the biopharmaceutical industry developing large-molecule analytical methods at AstraZeneca and Merck. At AstraZeneca/MedImmune, he developed a two-dimensional HPLC method that accurately characterizes mAbs and ADCs in high concentrations of a micelle-forming surfactant excipient. At Merck Research Laboratories, he developed high-throughput CE-SDS methods for a wide range of next-generation therapeutic proteins, including fusion proteins, bispecific engagers, Fc-peptide conjugates, and trispecific antibodies (in addition to traditional mAbs and ADCs).

Outside of the lab, you can find him sewing for fun or mountain biking around the Bay.

PAPERS
Hawe, C.; Tunink, K.; Wenger, D. “Krabbe Disease.” National Organization for Rare Disorders 2024, https://rarediseases.org/rare-diseases/leukodystrophy-krabbes/

Arruebarrena, M.A.; Hawe, C.T.; Lee, Y.M.; Branco, R.C. “Mechanisms of Cadmium Neurotoxicity.” International Journal of Molecular Sciences 2023, 24, 16558. https://doi.org/10.3390/ijms242316558